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公司名称:湖南晶科生物科技有限公司

地址:湖南省长沙市天心区解放西路466号汇源大厦1805室

电话:0731-84321919

传真:0731-85160101

Q Q:372403785、3504420063

邮箱:jingkebio@163.com

Immunosuppressive role of HMGB1 in TME

HMGB1 is a multifunctional protein with various roles in different cellular compartments. It exhibits a dual role in cancer cells; the intracellular HMGB1 acts as an anti-tumor protein stabilizing the genome, whereas the chronic released HMGB1 behaves as a pro-tumor protein with immunosuppressive functions.

In tumor microenvironment (TME), tumor cell-secreted HMGB1 inhibits the activities of T cells by inhibiting the maturation of dendritic cells (DCs) and promoting the activities of myeloid-derived suppressor cells (MDSCs) and Treg. HMGB1 also inhibits anti-tumor activity by binding to the immunosuppressive receptor TIM‐3. Moreover, HMGB1 interacts with RAGE and induces tumor cell migration, invasion and metastasis.

HMGB1 is a potential prognosis marker and a target for cancer therapy.  arigo offers quality antibodies and ELISA kits to facilitate the research of the detailed mechanism underlying the immune suppression by HMGB1.
 

HMGB1 ELISA kits and antibodies

  Reactivity: Hu
Sensitivity: 0.3 ng/ml
Sample: Plasma, cell culture sup.
    Reactivity: Ms, Rat
Sensitivity: 0.3 ng/ml
Sample: Plasma, cell culture sup., lysates
    Reactivity: Hu, Ms, Rat
Sensitivity: 0.15 ng/ml
Sample: Serum

 
 


HMGB1 antibody [SQab1711]
(ARG65863)


HMGB1 antibody [1F3]
(ARG10756)


HMGB1 antibody

(ARG65636)


 

Antibodies for MDSCs

 

Cat. No. Product Clonality Reactivity Application
ARG65463 CD11b antibody [ICRF44] Mouse mAb Hu, NHuPrm FACS, FuncSt, ICC/IF, IHC-Fr, IP
ARG54260 CD11b antibody [ICRF44] (PE) Mouse mAb Hu, NHuPrm FACS, ICC/IF, IHC-Fr
ARG22000 CD11b antibody [M1/70] Rat mAb Hu, Ms, Bb, Mk BL, FACS, ICC/IF, IHC-Fr, IHC-P, IP
ARG65478 CD11b antibody [M1/70] (APC) Rat mAb Hu, Ms, Bb, Mk FACS
ARG20843 CD11b antibody [3A33] (PE-Cy7) Rat mAb Ms FACS, ICC/IF
ARG65560 CD33 antibody [WM53] Mouse mAb Hu, NHuPrm FACS, FuncSt, ICC/IF, IHC-Fr, IP, WB
ARG22104 Ly6G/Ly6C antibody [RB6-8C5] Rat mAb Ms Depletion, FACS, IHC-Fr, IHC-P, IP

 

Antibodies for DCs

Cat. No. Product Clonality Reactivity Application
ARG21322 CD11c antibody [3.9] Mouse mAb Hu, Mk BL, FACS, IHC-Fr, IP
ARG23522 CD11c antibody [N418] Hamster mAb Ms FACS, ICC/IF, IHC-Fr, IP
ARG23079 Thrombomodulin antibody [QBEND/40] Mouse mAb Hu, Rb FACS, IHC-Fr, IHC-P

 

Antibodies for TAMs

 

Cat. No. Product Clonality Reactivity Application
ARG55553 F4/80 antibody [BM8] Rat mAb Hu, Ms FACS, IHC-Fr, WB
ARG53010 F4/80 antibody [SP115] Rabbit mAb Hu, Ms IHC-Fr, IHC-P, WB
ARG22838 CD163 antibody [EDHu-1] Mouse mAb Hu, Bo, Gpig, Pig, Mk, Sh ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB
ARG56138 CD163 antibody Rabbit pAb Hu, Ms, Rat FACS, IHC-P, WB
ARG55554 CD206 antibody [15-2] Mouse mAb Hu, Ms FACS, FuncSt, ICC/IF, IHC-Fr, IP, WB
ARG22456 CD206 antibody [MR5D3] Rat mAb Ms FACS, ICC/IF, IHC-Fr, IP
ARG22372 CD206 antibody Rabbit pAb Hu, Ms, Rat, Pig ICC/IF, IHC-P, WB

 

Antibodies for Treg

 

Cat. No. Product Clonality Reactivity Application
ARG21295 CD4 antibody [RFT4] Mouse mAb Hu FACS, ICC/IF, IHC-Fr, WB
ARG21979 CD4 antibody [GK1.5] Rat mAb Ms BL, Depletion, FACS, ICC/IF, IHC-Fr, IP
ARG65448 CD4 antibody [GK1.5] (PE) Rat mAb Ms FACS, ICC/IF, IHC-Fr
ARG65860 CD4 antibody [SQab1714] Rabbit mAb Hu FACS, IHC-P, IP, WB
ARG54202 FoxP3 antibody [3G3] Mouse mAb Hu, Ms FACS, WB
ARG53050 FoxP3 antibody [SP97] Rabbit mAb Hu IHC-P

 

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